Anti-Inflammatory and Gut Microbiota Modulation Potentials of Flavonoids Extracted from Passiflora foetida Fruits.
Xiangpeng HanYa SongRiming HuangMinqian ZhuMeiying LiTeresa RequenaHong WangPublished in: Foods (Basel, Switzerland) (2023)
This study aimed to explore the anti-inflammatory and gut microbiota modulation potentials of flavonoid-rich fraction (PFF) extracted from Passiflora foetida fruits. The results showed that PFF markedly reduced the production of nitric oxide (NO), tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6) in LPS-stimulated RAW 264.7 cells. Meanwhile, PFF treatment also effectively decreased the phosphorylation levels of MAPK, PI3K/Akt, and NF-κB signaling-pathway-related proteins (ERK, JNK, p38, Akt, and p65). Moreover, PFF had an impact on microbial composition and metabolites in a four-stage dynamic simulator of human gut microbiota (BFBL gut model). Specifically, PFF exhibited the growth-promoting ability of several beneficial bacteria, including Bifidobacterium , Enterococcus , Lactobacillus , and Roseburia , and short-chain fatty acid (SCFA) generation ability in gut microbiota. In addition, spectroscopic data revealed that PFF mainly contained five flavonoid compounds, which may be bioactive compounds with anti-inflammatory and gut microbiota modulation potentials. Therefore, PFF could be utilized as a natural anti-inflammatory agent or supplement to health products.
Keyphrases
- signaling pathway
- anti inflammatory
- pi k akt
- induced apoptosis
- cell cycle arrest
- epithelial mesenchymal transition
- nitric oxide
- rheumatoid arthritis
- cell proliferation
- fatty acid
- healthcare
- endothelial cells
- inflammatory response
- cell death
- staphylococcus aureus
- risk assessment
- electronic health record
- endoplasmic reticulum stress
- oxidative stress
- health promotion
- molecular docking
- human health
- nitric oxide synthase
- climate change
- immune response
- induced pluripotent stem cells