The efficacy and tolerability of rotigotine on patients with periodic limb movement in sleep: A systematic review and meta-analysis.

Meng-Ni WuPing-Tao TsengTien-Yu ChenYen-Wen ChenLi-Min LiouPao-Yen LinChung-Yao Hsu

Published in: PloS one (2018)

This meta-analysis revealed the considerable efficacy of rotigotine in alleviating the frequency of PLMS. However, the high withdrawal rate should be taken into account.

Keyphrases

systematic review
open label
physical activity
randomized controlled trial
case control
placebo controlled