Preeclampsia Prediction Using Machine Learning and Polygenic Risk Scores From Clinical and Genetic Risk Factors in Early and Late Pregnancies.
Vesela P KovachevaBraden W EberhardRaphael Y CohenMatthew MaherRicha SaxenaKathryn J Gray GusehPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
Integrating clinical factors into predictive models can inform personalized preeclampsia risk and achieve higher predictive power than the current practice. In the future, personalized tools can be implemented to identify high-risk patients for preventative therapies and timely intervention to improve adverse maternal and neonatal outcomes.
Keyphrases
- pregnancy outcomes
- risk factors
- end stage renal disease
- early onset
- ejection fraction
- newly diagnosed
- randomized controlled trial
- chronic kidney disease
- healthcare
- prognostic factors
- peritoneal dialysis
- type diabetes
- pregnant women
- metabolic syndrome
- gene expression
- dna methylation
- insulin resistance
- adipose tissue
- patient reported
- gestational age
- glycemic control
- weight loss
- weight gain