Comprehensive genetic characterization of rectal cancer in a large cohort of Japanese patients: differences according to tumor location.

Hitoshi HinoAkio ShiomiKeiichi HatakeyamaHiroyasu KagawaShoichi ManabeYusuke YamaokaTakeshi NagashimaKeiichi OhshimaKenichi UrakamiYasuto AkiyamaKen Yamaguchi

Published in: Journal of gastroenterology (2022)

Low RC exhibited distinct genetic characteristics from other RCs. In particular, CMS4 was more frequent in low RC and was a risk factor for poor prognosis. These findings potentially avail further information regarding tumor biology and could lead to improvements in RC treatment.

Keyphrases

poor prognosis
rectal cancer
long non coding rna
locally advanced
healthcare
gene expression
copy number
combination therapy
dna methylation
health information
smoking cessation