Dietary weight loss intervention improves subclinical atherosclerosis and oxidative stress markers in leukocytes of obese humans.
Sandra López-DomènechMayte Martínez-HerreraZaida Abad-JiménezCarlos MorillasIrene Escribano-LópezNoelia Díaz-MoralesCelia BañulsVíctor M VíctorMilagros RochaPublished in: International journal of obesity (2005) (2019)
Our findings reveal that the improvement of subclinical atherosclerotic markers after dietary weight loss intervention is associated with a reduction of oxidative stress in leukocytes and inflammatory pathways, suggesting that these are the underlying mechanisms responsible for the reduced risk of cardiovascular disease in obese subjects after losing weight.
Keyphrases
- weight loss
- oxidative stress
- cardiovascular disease
- bariatric surgery
- randomized controlled trial
- roux en y gastric bypass
- gastric bypass
- peripheral blood
- dna damage
- diabetic rats
- ischemia reperfusion injury
- induced apoptosis
- weight gain
- obese patients
- type diabetes
- genome wide
- cardiovascular events
- coronary artery disease
- gene expression
- dna methylation
- heat shock
- endoplasmic reticulum stress