Vaccines to prevent COVID-19: A living systematic review with Trial Sequential Analysis and network meta-analysis of randomized clinical trials.
Steven Kwasi KorangElena von RohdenAreti Angeliki VeronikiGiok OngOwen NgalamikaFaiza SiddiquiSophie JuulEmil Eik NielsenJoshua Buron FeinbergJohanne Juul PetersenChristian LegartAfoke KokoghoMathias MaagaardSarah KlingenbergLehana ThabaneAriel BardachAgustín CiapponiAllan Randrup ThomsenJanus C JakobsenChristian GluudPublished in: PloS one (2022)
The evidence suggests that all the included vaccines are effective in preventing COVID-19. The mRNA vaccines seem most effective in preventing COVID-19, but viral vector vaccines seem most effective in reducing mortality. Further trials and longer follow-up are necessary to provide better insight into the safety profile of these vaccines.