Blockade of dengue virus transmission from viremic blood to Aedes aegypti mosquitoes using human monoclonal antibodies.
Trung T VuHannah ClaphamVan Thi Thuy HuynhLong Vo ThiDui Le ThiNhu Tuyet VuGiang Thi NguyenTrang Thi Xuan HuynhKien Thi Hue DuongVi Thuy TranHuy Le Anh HuynhDuyen Thi Le HuynhThuy Le Phuong HuynhThuy Thi Van NguyenNguyen Minh NguyetTai Thi Hue LuongNguyen Thanh PhongChau Van Vinh NguyenGerald GoughBridget WillsLauren B CarringtonCameron P SimmonsPublished in: PLoS neglected tropical diseases (2019)
The results demonstrate that mAbs can neutralize infectious DENV derived from infected human cells, in the matrix of human blood. Coupled with previous evidence of their ability to prevent DENV infection of mammalian cells, such mAbs could be considered attractive antibody classes to elicit with dengue vaccines, or alternatively, for consideration as therapeutic candidates.