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Impaired Peyer's patch development in BOB.1/OBF.1-deficient mice.

Annika C BetzlerKatja FiedlerEnikö KokaiThomas WirthThomas K HoffmannCornelia Brunner
Published in: European journal of immunology (2021)
BOB.1/OBF.1 expression regulates the transcription of direct and indirect target genes. We propose that BOB.1/OBF.1 affects CXCL13-CXCR5 signaling of LTinducer and LTorganizer cells during embryonic Peyer's patch organogenesis as well as of B cells and follicular dendritic cells during lymphocyte homing at postnatal stages of secondary lymphoid organ development.
Keyphrases
  • dendritic cells
  • induced apoptosis
  • poor prognosis
  • preterm infants
  • immune response
  • cell cycle arrest
  • genome wide
  • gene expression
  • dna methylation
  • binding protein
  • cell death
  • cell migration