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Cell senescence, the senescence-associated secretory phenotype, and cancers.

Larissa G P Langhi PrataTamar TchkoniaJames L Kirkland
Published in: PLoS biology (2023)
Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can promote inflammation and cancer, eventually enabling the development of senolytic drugs.
Keyphrases
  • dna damage
  • endothelial cells
  • stress induced
  • cell fate
  • oxidative stress
  • papillary thyroid
  • single cell
  • cell therapy
  • stem cells
  • childhood cancer
  • lymph node metastasis
  • drug induced