A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series.
Travis NemkovFrancesca Isabelle CendaliMonika DzieciatkowskaDaniel StephensonKirk C HansenCatherine M JankowskiAngelo D'AlessandroRyan J MarkerPublished in: Pathophysiology : the official journal of the International Society for Pathophysiology (2024)
To molecularly characterize the impact of exercise on mitigating neoadjuvant treatment (NAT)-induced physical decline in pancreatic ductal adenocarcinoma (PDAC) patients, a multi-omics approach was employed for the analysis of plasma samples before and after a personalized exercise intervention. Consisting of personalized aerobic and resistance exercises, this intervention was associated with significant molecular changes that correlated with improvements in lean mass, appendicular skeletal muscle index (ASMI), and performance in the 400-m walk test (MWT) and sit-to-stand test. These alterations indicated exercise-induced modulation of inflammation and mitochondrial function markers. This case study provides proof-of-principal application for multiomics-based assessments of supervised exercise, thereby supporting this intervention as a feasible and beneficial intervention for PDAC patients to potentially enhance treatment response and patient quality of life. The molecular changes observed here underscore the importance of physical activity in cancer treatment protocols, advocating for the development of accessible multiomics-guided exercise programs for cancer patients.
Keyphrases
- physical activity
- high intensity
- randomized controlled trial
- end stage renal disease
- resistance training
- skeletal muscle
- chronic kidney disease
- newly diagnosed
- ejection fraction
- rectal cancer
- machine learning
- peritoneal dialysis
- stem cells
- public health
- lymph node
- oxidative stress
- patient reported outcomes
- body mass index
- prognostic factors
- case report
- mesenchymal stem cells
- squamous cell carcinoma
- bone marrow
- adipose tissue
- high glucose
- locally advanced
- body composition
- drug induced
- replacement therapy