MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases.

Koichi Ito Ibuki Harada Criseyda Martinez Katsutoshi Sato Eunjee Lee Elisa Port Jessica H Byerly Anupma Nayak Ekta Tripathi Jun Zhu Hanna Y Irie

Published in: Cancer research communications (2024)

EMT is a process directly linked to drug resistance and metastasis of cancer cells. We identified MARCH2 as a novel regulator of SNAIL, a key EMT driver, that promotes SNAIL ubiquitination and degradation in TNBC cells. MARCH2 is oncogene regulated and inhibits growth and metastasis of TNBC. These insights could contribute to novel strategies to therapeutically target TNBC.

Keyphrases

epithelial mesenchymal transition
signaling pathway
induced apoptosis
transcription factor
cell cycle arrest
pi k akt
cell death
cell proliferation