IL-20R Activation via rIL-19 Enhances Hematoma Resolution through the IL-20R1/ERK/Nrf2 Pathway in an Experimental GMH Rat Pup Model.

Shengpeng LiuJerry J FloresBo LiShuixiang DengGang ZuoJun PengJiping TangArne P Neyrinck

Published in: Oxidative medicine and cellular longevity (2021)

rIL-19 treatment improved hematoma clearance and attenuated neurological deficits induced by GMH, which was mediated through the upregulation of the IL-20R1/ERK/Nrf2 pathways. rIL-19 treatment may provide a promising therapeutic strategy for the GMH patient population.

Keyphrases

signaling pathway
oxidative stress
cell proliferation
traumatic brain injury
pi k akt
case report
poor prognosis
long non coding rna
brain injury
cerebral ischemia