Immunomodulatory Activity of a Traditional Sri Lankan Concoction of Coriandrum sativum L. and Coscinium fenestratum G.
Shashika Dinethri KothalawalaDaniya EdwardJayamini C HarasgamaLoshini RanaweeraOvitigala Vithanage Don Sisira Jagathpriya WeerasenaRoshan NiloofaWanigasekera Daya RatnasooriyaGalbada Arachchige Sirimal PremakumaraShiroma M HandunnettiPublished in: Evidence-based complementary and alternative medicine : eCAM (2020)
The traditional Sri Lankan concoction of C. sativum and C. fenestratum demonstrated potent in vivo anti-inflammatory activity, significant reduction of ROS, and NO production by rat peritoneal cells and the lack of iNOS expression confirmed the low NO production. The increased membrane stability also supports the anti-inflammatory activity of the concoction. Further, this concoction induced a significantly high antibody response reflecting its immunostimulatory activity. Together these results scientifically validate the therapeutic use of the concoction of C. sativum and C. fenestratum in Sri Lankan traditional medicinal system for immunomodulatory effects.