Evaluation of the molecular origin of amide proton transfer-weighted imaging.
Casey SunYu ZhaoZhongliang ZuPublished in: Magnetic resonance in medicine (2023)
The positive APTw signal using high saturation amplitudes could have significant contributions from soluble proteins through CEST, including amide/amine/guanidine proton transfer effects. In contrast, the negative APTw signal using low saturation amplitudes has significant contribution from lipids through rNOE.