Activation of AKT/mammalian target of rapamycin signaling in the peripheral blood of women with premature ovarian insufficiency and its correlation with FMR1 expression.

Julia RehnitzBirgitta MessmerUlrike BenderXuan Phuoc NguyenAriane GermeyerKatrin HinderhoferThomas StrowitzkiEdison Capp

Published in: Reproductive biology and endocrinology : RB&E (2022)

In Premature ovarian insufficiency patients, activation of AKT/mTOR signaling pathway is remarkable and putatively pathognomonic. Additionally, it seems to be triggered by an FMR1/mTOR/S6K linkage mechanism, most relevant in premutation carriers.

Keyphrases

signaling pathway
cell proliferation
peripheral blood
end stage renal disease
chronic kidney disease
pi k akt
ejection fraction
poor prognosis
newly diagnosed
prognostic factors
induced apoptosis
patient reported outcomes
hepatitis c virus
hiv infected
antiretroviral therapy