Randomised clinical trial: a phase 1b study of GB004, an oral HIF-1α stabiliser, for treatment of ulcerative colitis.

Silvio DaneseBarrett G LevesqueBrian G FeaganAlina JucovBal Raj BhandariRish K PaiKristen Taylor MeadowsBrian J KirbyJean-Marie BrueyAllan OlsonRobin OsterhoutCourtney Van BieneJulia FordRichard ArandaKartik RaghupathiWilliam J Sandborn

Published in: Alimentary pharmacology & therapeutics (2022)

Results from this phase 1b trial support evaluation of the full therapeutic potential of GB004 for the treatment of UC. A phase 2 study (NCT04556383) is ongoing. Clinicaltrials.gov NCT03860896.

Keyphrases

clinical trial
open label
study protocol
ulcerative colitis
phase ii
phase iii
randomized controlled trial
endothelial cells