GluN2C selective inhibition is a target to develop new antiepileptic compounds.

Svetlana GataullinaGilles GalvaniSabrina TouchetCaroline NousÉric LemaireJacques LaschetCatherine Chiron Olivier DulacElena DossiJean-Daniel BrionSamir MessaoudiMouad AlamiGilles Huberfeld

Published in: Epilepsia (2022)

Subunit-selective inhibition is a valuable target for developing drugs for severe epilepsies resulting from an upregulation of NMDA-R subunit-mediated transmission.

Keyphrases

cell proliferation
protein kinase
poor prognosis
early onset
signaling pathway
drug induced