High-fat-diet-induced obesity promotes simultaneous progression of lung cancer and atherosclerosis in apolipoprotein E-knockout mice.
Yihao WangKaixin YanHan DuanNing TaoShaoning ZhuYuning ZhangYonggang YouZhen ZhangHua WangShunying HuPublished in: Cancer innovation (2024)
In this study, HFD-induced obesity could simultaneously promote progression of lung cancer and atherosclerosis in the same mouse. HFD-induced upregulation of LOX-1 may play an important role in the simultaneous progression of these two conditions via the inflammatory response and VEGF.
Keyphrases
- high fat diet induced
- insulin resistance
- high fat diet
- inflammatory response
- high glucose
- metabolic syndrome
- diabetic rats
- weight loss
- type diabetes
- cardiovascular disease
- endothelial cells
- adipose tissue
- weight gain
- poor prognosis
- drug induced
- vascular endothelial growth factor
- signaling pathway
- oxidative stress
- lipopolysaccharide induced
- toll like receptor
- body mass index