Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis.
Lucien G J CayerArun SurendranTobias K KarakachHarold M AukemaAmir RavandiPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Our comprehensive analysis of oxylipins in the human AV identified the inflammatory and osteogenic regulating prostanoids to be positively correlated with AVS severity. This elucidation of prostanoid dysregulation warrants further research into COX inhibition to mitigate AVS.