Preclinical PET Studies of [11C]UCB-J Binding in Minipig Brain.
Majken Borup ThomsenAnna Christina SchachtAage Kristian Olsen AlstrupJan JacobsenThea Pinholt LillethorupSimone Larsen BærentzenOve NoerDariusz OrlowskiBetina ElfvingHeidi Kaastrup MüllerDavid J BrooksAnne Marlene LandauPublished in: Molecular imaging and biology (2021)
[11C]UCB-J PET is a valid in vivo marker of synaptic density in the minipig brain, with binding values close to those reported for humans. Minipig models of disease could be valuable for investigating the efficacy of putative neuroprotective agents for preserving synaptic function in future non-invasive, longitudinal studies.
Keyphrases
- cerebral ischemia
- resting state
- white matter
- pet ct
- computed tomography
- positron emission tomography
- case control
- functional connectivity
- prefrontal cortex
- dna binding
- multiple sclerosis
- cross sectional
- subarachnoid hemorrhage
- stem cells
- brain injury
- cell therapy
- blood brain barrier
- bone marrow
- mesenchymal stem cells