Differences in Sex-Specific Frequency of Glucocerebrosidase Variant Carriers and Familial Parkinsonism.
Roberto A OrtegaSusan B BressmanDeborah RaymondLaurie J OzeliusViktoriya KatsnelsonKatherine LeaverMatthew C SwanVicki ShankerJoan MiraviteCuiling WangSteffany A L BennettRachel Saunders-PullmanPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
Our study demonstrates that the male-sex predominance present in GBA PD overall was not consistent across GBA variant severities, and a female-sex predominance was present among severe GBA variant carriers. Therefore, research and trial designs for PD should consider sex-specific differences, including across GBA variant severities. © 2022 International Parkinson and Movement Disorder Society.