Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp).
Felipe Moura Araújo da SilvaKatia Pacheco A da SilvaLuiz Paulo M de OliveiraEmmanoel V CostaHector Hf KoolenMaria Lúcia B PinheiroAntonia Queiroz L de SouzaAfonso Duarte Leão de SouzaPublished in: Memorias do Instituto Oswaldo Cruz (2020)
Overall, these results suggest that both flavonoid glycosides and their putative human metabolites can play a key role as inhibitors of the SARS-CoV-2 3CLpro and RdRp. Obviously, further researches, mainly in vitro and in vivo experiments, are necessary to certify the docking results reported here, as well as the adequate application of these substances. Furthermore, it is necessary to investigate the risks of D. ambrosioides as a phytomedicine for use against COVID-19.