Pathobiological role of cleft palate transmembrane protein 1 family proteins in oral squamous cell carcinoma.

Keisuke InoueKiichi HatanoYuki HanamatsuChiemi SaigoYusuke KitoKatsuaki BunaiToshiyuki ShibataTamotsu Takeuchi

Published in: Journal of cancer research and clinical oncology (2019)

Clptm1 and CRR9 were overexpressed in many OSCC tissues. In particular, CRR9 expression may promote tumor development and have a significant poor prognostic value in OSCC, possibly through conferring invasion ability and resistance to apoptotic stimuli possibly related to Bcl-xL expression. CRR9 could be a novel molecular target for patients with OSCC.

Keyphrases

poor prognosis
binding protein
cell death
gene expression
cell migration
anti inflammatory
protein protein
single molecule
small molecule