Impact of Radiation Therapy on Biological Parameters in Cancer Patients: Sub-analysis from the RIT Prospective Epidemiological Study.
Nicolas MagnéElisabeth DagunetWafa BouleftourLaurine ConrauxFabien TinquautKevin GrangeonPablo Moreno-AcostaJean-Philippe SuchaudChloé RancouleJean-Baptiste GuyPublished in: Cancer investigation (2022)
Scarce data investigate the impact of radiotherapy (RT) on biology markers. An analysis of ancillary study of RIT (Radiation Impact on Thromboembolic events) prospective trial was carried out. All patients with non-metastatic solid tumors and treated with radiotherapy and/or brachytherapy in curative and consenting to have blood samples were included. A significant decrease in white blood count, (i.e. lymphocytes, monocytes, neutrophils and basophils) and platelet counts was observed after RT and maintained at 6 months. Whereas, eosinophils, D-dimers and hemoglobin levels were affected respectively 3 months and 6 months after RT initiation. Conversely, red cells count and CRP level were not affected by RT. This study is an advocacy to develop an understanding of basic immune system in relation with RT.
Keyphrases
- radiation therapy
- peripheral blood
- locally advanced
- radiation induced
- early stage
- squamous cell carcinoma
- induced apoptosis
- small cell lung cancer
- high dose
- clinical trial
- rectal cancer
- randomized controlled trial
- cell proliferation
- dendritic cells
- atrial fibrillation
- big data
- endoplasmic reticulum stress
- deep learning
- artificial intelligence
- prognostic factors