Paracetamol and ibuprofen combination for the management of acute mild-to-moderate pain in children: expert consensus using the Nominal Group Technique (NGT).
Niccolò ParriDavide SilvagniAlberto ChiarugiElisabetta CortisAntonio D'AvinoMarcello LanariPaola Giovanna MarchisioCesare VezzoliStefania ZampognaAnnamaria StaianoPublished in: Italian journal of pediatrics (2023)
The use of the fixed-dose combination may represent advantage in terms of efficacy and safety, allowing a better control of the dose of both paracetamol and ibuprofen as monotherapy, thus minimizing the risk of incorrect dosage. However, the limited evidence available highlights the need for future well designed studies to better define the advantages of this formulation in the various therapeutic areas.
Keyphrases
- liver failure
- postoperative pain
- chronic pain
- young adults
- drug delivery
- pain management
- respiratory failure
- current status
- anti inflammatory drugs
- open label
- drug induced
- randomized controlled trial
- clinical trial
- spinal cord injury
- hepatitis b virus
- study protocol
- mechanical ventilation
- extracorporeal membrane oxygenation