Older adults' adherence to medications and willingness to deprescribe: A sub-study of a randomized clinical trial.
Kristie Rebecca WeirKatharina Tabea JungoSven StreitPublished in: British journal of clinical pharmacology (2023)
Our study investigated the association between patients' willingness to have medications deprescribed and medication adherence. This longitudinal sub-study of the 'Optimizing PharmacoTherapy In the Multimorbid Elderly in Primary CAre' (OPTICA) trial, a cluster randomized controlled trial, took place in Swiss primary care settings. Participants were aged ≥65 years and over, with ≥3 chronic conditions, and ≥5 regular medications. At baseline the 'revised Patient Attitudes Towards Deprescribing' (rPATD) questionnaire was measured. The A14-scale measured adherence (self-report) at the 12-month follow-up. Multilevel linear regression analyses adjusted for baseline variables were performed. Of the 298 participants, 45% were women and the median age was 78. Participants reported a high level of adherence and willingness to have medications deprescribed. We did not find evidence for an association between patients' willingness to deprescribe and medication adherence. Further research is needed to explore the relationship between these concepts and to inform collaborative decisions about medicines in the context of polypharmacy.
Keyphrases
- primary care
- end stage renal disease
- ejection fraction
- prognostic factors
- clinical trial
- peritoneal dialysis
- study protocol
- emergency department
- metabolic syndrome
- patient reported outcomes
- smoking cessation
- case report
- skeletal muscle
- cross sectional
- insulin resistance
- quality improvement
- phase iii
- glycemic control
- breast cancer risk
- neural network