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Peripheral blood mononuclear cell transcriptome profile in a clinical trial with subcutaneous, grass pollen allergoid immunotherapy.

Sviatlana StarchenkaKemi OluwayiMatthew D HeathOliver ArmfieldM H Mohamed ShamjiJanice A LayhadiKatarzyna LisLisa CadavezOlesya RusynMurray SkinnerPieter-Jan De Kam
Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2024)
Peripheral blood mononuclear cells transcriptome profile showed an inhibition of Th2, Th17 pro-inflammatory allergic responses and immune deviation towards Th1 responses. PQ Grass extended regimen exhibited a superior mechanistic efficacy profile in comparison with PQ conventional regimen.
Keyphrases
  • peripheral blood
  • single cell
  • clinical trial
  • rna seq
  • gene expression
  • genome wide
  • cell therapy
  • randomized controlled trial
  • phase iii