Peripheral blood mononuclear cell transcriptome profile in a clinical trial with subcutaneous, grass pollen allergoid immunotherapy.

Sviatlana Starchenka Kemi Oluwayi Matthew D Heath Oliver Armfield M H Mohamed Shamji Janice A Layhadi Katarzyna Lis Lisa Cadavez Olesya Rusyn Murray Skinner Pieter-Jan De Kam

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2024)

Peripheral blood mononuclear cells transcriptome profile showed an inhibition of Th2, Th17 pro-inflammatory allergic responses and immune deviation towards Th1 responses. PQ Grass extended regimen exhibited a superior mechanistic efficacy profile in comparison with PQ conventional regimen.

Keyphrases

peripheral blood
single cell
clinical trial
rna seq
gene expression
genome wide
cell therapy
randomized controlled trial
phase iii