Antimicrobial activity of carvacrol and its derivatives on Mycobacterium spp.: systematic review of preclinical studies.
Thiago H FermianoJoão V Perez de SouzaLetícia Sayuri MuraseJoão P Salvaterra PasquiniRegiane B de Lima ScodroPaula A Zanetti Campanerut-SáKatiany Rizzieri Caleffi-FerracioliVera L Dias SiqueiraJean E MeneguelloJorge J Vieira TeixeiraRosilene Fressatti CardosoPublished in: Future medicinal chemistry (2024)
Background: The scope of the study was to analyze original preclinical studies on the antimicrobial effects of carvacrol and derivatives on the Mycobacterium genus. Materials & methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, four databases (PubMed, Web of Science, SCOPUS and EMBASE) were searched. Results: The search retrieved 392 records, of which 11 papers were selected. Heterogeneity in the techniques and mycobacterial targets was observed. Carvacrol demonstrated synergistic antimycobacterial activity with rifampicin against multidrug-resistant Mycobacterium tuberculosis on membranes and biofilms. In silico approaches showed specific targets in mycobacteria, by inhibition and molecular docking assays, on the enzyme chorismate mutase and the heat shock protein 16.3. Conclusion: Carvacrol has been shown to be a scaffold candidate for future molecules with activity against mycobacteria.
Keyphrases
- mycobacterium tuberculosis
- meta analyses
- molecular docking
- systematic review
- heat shock protein
- multidrug resistant
- pulmonary tuberculosis
- randomized controlled trial
- molecular dynamics simulations
- case control
- cell therapy
- heat shock
- public health
- staphylococcus aureus
- drug resistant
- high throughput
- gram negative
- stem cells
- candida albicans
- acinetobacter baumannii
- big data
- emergency department
- escherichia coli
- cancer therapy
- klebsiella pneumoniae
- machine learning
- heat stress
- cystic fibrosis