Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias.
Breton M AskenJeremy A TannerLawren VandevredeAlexandra AppleMarianne ChapleauLeslie S GaynorCourtney Lane-DonovanSteven LenioGolnaz YadollahikhalesShannon LeeEva GontrumMarguerite KnudtsonLeonardo IaccarinoRenaud La JoieYann CobigoAdam M StaffaroniKaitlin B CasalettoRaquel C GardnerLea T GrinbergMaria Luisa Gorno-TempiniHoward J RosenWilliam W SeeleyBruce L MillerJoel KramerGil D RabinoviciPublished in: Neurology (2024)
Among older adults with and without neurodegenerative disease, risk of CSP is driven more by duration (years) of RHI, especially American football, than number of TBI. CSP length (≥6 mm) is relatively specific to individuals who have had substantial prior RHI. Neurodegenerative disease and progressive atrophy do not clearly influence development or worsening of CSP.