Testing the PPAR hypothesis of tobacco use disorder in humans: A randomized trial of the impact of gemfibrozil (a partial PPARα agonist) in smokers.

Marie N S GendyPatricia Di CianoWilliam J KowalczykSean P BarrettTony P GeorgeStephen HeishmanBernard Le Foll

Published in: PloS one (2018)

Although preclinical studies with PPAR α agonists showed promising results, this preliminary study did not demonstrate positive effect of gemfibrozil on tobacco use and cessation indices.

Keyphrases

insulin resistance
fatty acid
smoking cessation
type diabetes
stem cells
metabolic syndrome
skeletal muscle
cell therapy
mesenchymal stem cells
case control