Cholesteryl Ester Promotes Mammary Tumor Growth in MMTV-PyMT Mice and Activates Akt-mTOR Pathway in Tumor Cells.
Lengyun WeiXuyang LuShengmei WengShenglong ZhuYongquan ChenPublished in: Biomolecules (2021)
The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T) transgenic mice and breast tumor cell MCF-7, we show that both exogenous and endogenous CE can increase mammary tumor growth, that CE upregulates the AKT/mTOR pathway, and that CE synthesis blockade suppresses this signaling pathway. Our data suggest that SOAT1, a sterol O-acyltransferase, may be a potential target for the treatment of breast cancer.
Keyphrases
- signaling pathway
- cell proliferation
- energy transfer
- poor prognosis
- pi k akt
- epithelial mesenchymal transition
- induced apoptosis
- stem cells
- single cell
- breast cancer cells
- big data
- electronic health record
- mesenchymal stem cells
- metabolic syndrome
- long non coding rna
- climate change
- skeletal muscle
- combination therapy
- smoking cessation
- young adults
- replacement therapy