PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin.

Lai WeiPengcheng LiYuan LuoMeiyu ZhangTing YanYue YangYuchen HanShuli LiuEnhua Wang

Published in: OncoTargets and therapy (2020)

PWP1 expression in NSCLC was correlated with poor prognosis. PWP1 enhanced the activity of the Wnt pathway by interacting with DVL2, whereas PWP1 inhibited the activity of the Hippo pathway by interacting with Merlin. Together, these two effects promoted the detrimental biological behaviors of NSCLC cells.

Keyphrases

poor prognosis
long non coding rna
small cell lung cancer
protein kinase
induced apoptosis
advanced non small cell lung cancer
stem cells
cell cycle arrest
cell proliferation
brain metastases
oxidative stress
endoplasmic reticulum stress
cell death
binding protein