Predicting Response to Brain Stimulation in Depression: a Roadmap for Biomarker Discovery.
Camilla L NordPublished in: Current behavioral neuroscience reports (2021)
A pragmatic framework for discovery and testing of biomarkers of brain stimulation response in depression is proposed, involving (1) identification of a cognitive-neural phenotype; (2) confirming its validity as putative biomarker, including out-of-sample replicability and within-subject reliability; (3) establishing the association between this phenotype and treatment response and/or its modifiability with particular brain stimulation interventions via an early-phase randomised controlled trial RCT; and (4) multi-site RCTs of one or more treatment types measuring the generalisability of the biomarker and confirming the superiority of biomarker-selected patients over randomly allocated groups.
Keyphrases
- resting state
- white matter
- end stage renal disease
- small molecule
- depressive symptoms
- study protocol
- ejection fraction
- functional connectivity
- newly diagnosed
- chronic kidney disease
- high throughput
- cerebral ischemia
- randomized controlled trial
- peritoneal dialysis
- physical activity
- clinical trial
- patient reported outcomes
- blood brain barrier
- replacement therapy