N-palmitoylethanolamide synergizes the antinociception of morphine and gabapentin in the formalin test in mice.

Myrna Déciga-CamposOsmar Antonio Jaramillo-MoralesJosué Vidal Espinosa-JuárezMaría Elena Aguilera-MartínezRosa Ventura-MartínezFrancisco Javier López-Muñoz

Published in: The Journal of pharmacy and pharmacology (2023)

These results suggest that MOR and GBP synergistically enhance PEA-induced antinociception through PPARα and opioid receptor mechanisms. Furthermore, the results suggest that combinations containing PEA with MOR or GBP could be of interest in aiding the treatment of inflammatory pain.

Keyphrases

chronic pain
pain management
neuropathic pain
diabetic rats
oxidative stress
insulin resistance
spinal cord injury
spinal cord
metabolic syndrome
drug induced
fatty acid
adipose tissue
binding protein
combination therapy
skeletal muscle
replacement therapy
smoking cessation