Episodic viral wheeze and multiple-trigger wheeze in preschool children are neither distinct nor constant patterns. A prospective multicenter cohort study in secondary care.
Maud J A RaaymakersPaul L P BrandAnneke M LandstraMarianne L BrouwerWalter A F BalemansLaetitia E M NiersPeter J F M MerkusAnnemie L M BoehmerJan A J W KluytmansJohan C de JongsteMarielle W H PijnenburgAnja A P H Vaessen-VerbernePublished in: Pediatric pulmonology (2019)
This study shows that EVW and MTW are variable over time within patients. Pediatrician classification of these phenotypes based on clinical history does not correspond to prospectively recorded symptom patterns. The applicability of these phenotypes as a basis for therapeutic decisions and prognosis should be questioned.