The CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression.
Yihao LiuXuelong WangYouwei ZhuYizhi CaoLiwen WangFanlu LiYu ZhangYing LiZhiqiang ZhangJiaxin LuoXiaxing DengChenghong PengGang WeiHao ChenBaiyong ShenPublished in: Clinical and translational medicine (2022)
Our study demonstrated a novel epigenetic regulation mechanism of promoting pro-tumour M2-polarised TAMs in the PDAC tumour microenvironment.