Microtomographic, histomorphometric, and molecular features show a normal alveolar bone healing process in iNOS-deficient mice along a compensatory upregulation of eNOS and nNOS isoforms.
Carolina Fávaro FrancisconiPriscila Maria ColaviteAngélica Cristina FonsecaMichelle de Campos Soriani AzevedoAndré Petenuci TabanezJéssica Lima MelchiadesAndreia Espíndola VieiraCarlos Eduardo Palanch RepekeMarcela ClaudinoGustavo Pompermaier GarletPublished in: Journal of applied oral science : revista FOB (2023)
The absence of iNOS does not result in a significant modulation of bone healing readouts in iNOS-KO mice. The upregulation of nNOS and eNOS may compensate iNOS absence, explaining the similar bone healing outcome in WT and iNOS-KO strains.