Effects of Age and Diet on Triglyceride Metabolism in Mice.
Kathryn M SpitlerShwetha Kumari ShettyBrandon S J DaviesPublished in: bioRxiv : the preprint server for biology (2024)
The changes in triglyceride metabolism that occur with age in humans are not reflected in a mouse model, thus mice are likely not an ideal model for understanding how age impacts lipid metabolism and subsequent metabolic disease.A fish-oil based high-fat diet high in omega-3 fatty acids significantly increases fatty acid uptake in the heart while at the same time decreases fasting insulin levels.In future studies it will be important to understand how the omega-3 fatty acid induced increase in fatty acid uptake affects cardiac function and how it is related to other phenotypes induced by omega-3 fatty acids.