Activated intestinal muscle cells promote preadipocyte migration: a novel mechanism for creeping fat formation in Crohn's disease.

Ren MaoGenevieve DoyonIlyssa O GordonJiannan LiSinan LinJie WangThi Hong Nga LeMichael EliasSatya KuradaBrian SouthernMitchell OlmanMinhu ChenShuai ZhaoDina DejanovicJyotsna ChandraPranab K MukherjeeGail WestDavid R Van WagonerClaudio FiocchiFlorian Rieders

Published in: Gut (2021)

Crohn's disease creeping fat appears to result from the migration of preadipocytes out of mesenteric fat and differentiation into adipocytes in response to an increased production of fibronectin by activated muscularis propria cells. These new mechanistic insights may lead to novel approaches for prevention of creeping fat-associated stricture formation.

Keyphrases

adipose tissue
induced apoptosis
cell cycle arrest
fatty acid
skeletal muscle
endoplasmic reticulum stress
oxidative stress
cell death
type diabetes
metabolic syndrome