Predictivity of Nonclinical Male Reproductive Findings for Human Effects.

Anthony R ScialliRichard V ClarkRobert E Chapin

Published in: Birth defects research (2017)

In this sample of compounds, nonclinical studies appeared to over-predict reproductive toxicity in men. We identified possible reasons for the apparent lack of predictivity of the experimental animal studies. Birth Defects Research 110:17-26, 2018. © 2017 Wiley Periodicals, Inc.

Keyphrases

endothelial cells
case control
oxidative stress
magnetic resonance imaging
computed tomography
gestational age
pluripotent stem cells
diffusion weighted imaging
preterm birth