The CCL20 and CCR6 axis in psoriasis.
Kazuhisa FurueTakamichi ItoGaku TsujiTakeshi NakaharaMasutaka FuruePublished in: Scandinavian journal of immunology (2019)
Psoriasis is a TNF-α/IL-23/IL-17A-mediated inflammatory skin disease that causes a significant socioeconomic burden in afflicted patients. IL-17A-producing immune cells, including Th17 cells, are crucial effector cells in the development of psoriasis. IL-17A stimulates epidermal keratinocytes to produce CCL20, which eventually recruits CCR6 + Th17 cells into the lesional skin. Thus, the CCL20/CCR6 axis works as a driving force that prepares an IL-17A-rich cutaneous milieu. In this review, we summarize the current research topics on the CCL20/CCR6 axis and the therapeutic intervention of this axis for psoriasis.
Keyphrases
- induced apoptosis
- cell cycle arrest
- dendritic cells
- regulatory t cells
- liver injury
- randomized controlled trial
- end stage renal disease
- rheumatoid arthritis
- cell death
- oxidative stress
- newly diagnosed
- endoplasmic reticulum stress
- ejection fraction
- signaling pathway
- peritoneal dialysis
- cell proliferation
- soft tissue
- immune response
- risk factors
- patient reported outcomes