A Randomized Placebo-Controlled N-of-1 Trial: The Effect of Proton Pump Inhibitor in the Management of Gastroesophageal Reflux Disease.

Fernando Sierra-ArangoD M CastañoJennifer D ForeroErika D Pérez-RiverosGerardo Ardila DuarteMaria L BoteroAndres CárdenasJosé Antonio de la Hoz-Valle

Published in: Canadian journal of gastroenterology & hepatology (2019)

There was no significant improvement in the patient GERD symptoms increasing the dose of oral esomeprazole during the 6 months of study. N-of-1 trials in chronic pathologies including GERD are recommended due to their potential value as systematic methods that evaluate therapies without strong scientific evidence.

Keyphrases

gastroesophageal reflux disease
study protocol
phase iii
placebo controlled
phase ii
clinical trial
case report
double blind
randomized controlled trial
squamous cell carcinoma
open label
radiation therapy
human health
phase ii study
electron transfer