Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy.
Paola Di BenedettoVasiliki LiakouliPiero RuscittiOnorina BerardicurtiFrancesco CarubbiNoemi PanzeraSalvatore Di BartolomeoGiuliana GugginoFrancesco CicciaGiovanni TrioloPaola CiprianiRoberto GiacomelliPublished in: Arthritis research & therapy (2018)
CD248 overexpression may play an important role in the fibrotic process by modulating the molecular target, leading to perivascular cells differentiation toward myofibroblasts and interfering with its expression, and thus might open a new therapeutic strategy to inhibit myofibroblast generation during SSc.
Keyphrases
- systemic sclerosis
- interstitial lung disease
- induced apoptosis
- signaling pathway
- poor prognosis
- cell cycle arrest
- pulmonary fibrosis
- minimally invasive
- nk cells
- cell proliferation
- transforming growth factor
- transcription factor
- oxidative stress
- binding protein
- endoplasmic reticulum stress
- mesenchymal stem cells
- stem cells
- epithelial mesenchymal transition
- long non coding rna
- human health
- rheumatoid arthritis