The effects of aripiprazole and olanzapine on pupillary light reflex and its relationship with pharmacogenetics in a randomized multiple-dose trial.
Dora KollerMiriam Saiz-RodríguezPablo ZubiaurDolores OchoaSusana AlmenaraManuel RománDaniel Romero-PalaciánAlejandro de Miguel-CáceresSamuel MartínMarcos Navares-GómezGina MejíaAneta WojniczFrancisco Abad-SantosPublished in: British journal of clinical pharmacology (2020)
In conclusion, aripiprazole and its main metabolite, dehydro-aripiprazole altered pupil contraction, but olanzapine did not have such an effect. Many polymorphisms may influence pupillometric parameters and several polymorphisms had an effect on aripiprazole, dehydro-aripiprazole and olanzapine pharmacokinetics. Pupillography could be a useful tool for the determination of autonomic nerve activity during antipsychotic treatment.