Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway.

Ming-Hao GeHe TianLiang MaoDao-Yong LiJia-Quan LinHeng-Shuo HuShuo-Cheng HuangChuan-Jie ZhangXi-Fan Mei

Published in: CNS neuroscience & therapeutics (2021)

Zinc promoted the degradation of oxidative stress products and lipid peroxides through the NRF2/HO-1 and GPX4 signaling pathways to inhibit ferroptosis in neurons.

Keyphrases

spinal cord
oxidative stress
signaling pathway
cell death
oxide nanoparticles
induced apoptosis
pi k akt
neuropathic pain
spinal cord injury
diabetic rats
ischemia reperfusion injury
dna damage
epithelial mesenchymal transition
fatty acid