Early upregulation of AR and steroidogenesis enzyme expression after 3 months of androgen-deprivation therapy.

Agus Rizal Ardy Hariandy HamidHarun W Kusuma PutraNingrum Paramita SariPutri DianaSaras Serani SesariEka NovitaFajar Lamhot GultomMeilania SaraswatiBudiana Tanurahardjanull AsmarinahRainy UmbasChaidir A Mochtar

Published in: BMC urology (2020)

AR and steroidogenic enzymes are upregulated in ADT-PCa patients as early as 3 months, without PSA elevation. Steroidogenic enzymes, particularly SRD5A3, were also upregulated before PSA rose.

Keyphrases

prostate cancer
poor prognosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
radical prostatectomy
prognostic factors
stem cells
bone marrow
binding protein