The cross talk between type II diabetic microenvironment and the regenerative capacities of human adipose tissue-derived pericytes: a promising cell therapy.
Toka A AhmedSara M AhmedHoda ElkhenanyMohamed A El-DesoukySameh MagdeldinAya OsamaAli Mostafa AnwarIhab K MohamedMohamed Essameldin AbdelgawadDemiana H HannaNagwa El-BadriPublished in: Stem cell research & therapy (2024)
These data showed that the diabetic microenvironment exert a deleterious effect on the regenerative capacities of human adipose tissue-derived PCs, and may thus have possible implications on the vascular complications of T2DM. Nevertheless, PCs have shown remarkable protective mechanisms when initially exposed to DS and thus they could provide a promising cellular therapy for T2DM.
Keyphrases
- cell therapy
- stem cells
- adipose tissue
- endothelial cells
- mesenchymal stem cells
- type diabetes
- insulin resistance
- high fat diet
- induced pluripotent stem cells
- wound healing
- pluripotent stem cells
- risk factors
- big data
- machine learning
- electronic health record
- glycemic control
- bone marrow
- weight loss
- artificial intelligence
- deep learning