Nitroisobenzofuranone, a small molecule inhibitor of multidrug-resistant Staphylococcus aureus , targets peptidoglycan biosynthesis.
Viral RawatSona TiwariShweta KhannaUmang GuptaSridhar S N CDharmendra K YadavGrace KaulAbdul AkhirDeepanshi SaxenaMatheshwaran SaravananSidharth ChopraDharmaraja AllimuthuPublished in: Chemical communications (Cambridge, England) (2022)
Antimicrobial resistance (AMR) is a global health concern. Targetting AMR, we present an in situ lactonization mechanism generating 4-nitroisobenzofuran-1(3 H )-one (IITK2020), an exclusive S. aureus inhibitor at 2-4 μg mL -1 MIC including multidrug-resistant S. aureus clinical strains, that prevents peptidoglycan biosynthesis.
Keyphrases
- antimicrobial resistance
- multidrug resistant
- cell wall
- global health
- small molecule
- staphylococcus aureus
- drug resistant
- gram negative
- acinetobacter baumannii
- public health
- klebsiella pneumoniae
- escherichia coli
- protein protein
- biofilm formation
- mouse model
- pseudomonas aeruginosa
- methicillin resistant staphylococcus aureus
- candida albicans