Analysis of the estrogen receptor-associated lncRNA landscape identifies a role for ERLC1 in breast cancer progression.
Hui YuanLinlin YanMingming WuYinzhong ShangQianying GuoXin MaXiao ZhangYong ZhuZhengsheng WuPeter E LobieTao ZhuPublished in: Cancer research (2021)
Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and in breast cancer. By cross-analyzing The Cancer Genome Atlas (TCGA) database, ERα-regulated long noncoding RNA 1 (ERLC1) was identified as a long noncoding RNA exhibiting a strong association with ERα signaling and high specificity of expression in breast tissue. ERLC1 was transcriptionally activated by ERα, and ERLC1 stabilized the ESR1 transcript by sequestering miR-129 and tethering FXR1 to maintain a positive feedback loop that potentiated ERα signaling. ERLC1 was elevated in tamoxifen-resistant breast cancer cells, where ERLC1 depletion restored sensitivity to tamoxifen and increased the efficacy of palbociclib or fulvestrant therapy. Collectively, these data warrant further investigation of ERLC1 as a modulator of therapeutic response and potential therapeutic target in ER+ breast cancer.
Keyphrases
- estrogen receptor
- long noncoding rna
- breast cancer cells
- long non coding rna
- poor prognosis
- genome wide
- transcription factor
- single cell
- cell proliferation
- papillary thyroid
- gene expression
- big data
- dna methylation
- metastatic breast cancer
- lymph node metastasis
- binding protein
- endoplasmic reticulum
- mesenchymal stem cells
- replacement therapy
- squamous cell
- data analysis
- smoking cessation