Bone morphogenetic protein 4 rescues the bone regenerative potential of old muscle-derived stem cells via regulation of cell cycle inhibitors.

Haizi ChengXueqin GaoMatthieu HuardAiping LuJoseph J RuzbarskySara AmraBing WangXueqin Gao

Published in: Stem cell research & therapy (2022)

In summary, BMP4 can offset the adverse effect of aging on the osteogenic differentiation and the bone regenerative potential of old MDSCs via up-regulation of P18 and down-regulation P16 expression.

Keyphrases

stem cells
cell cycle
mesenchymal stem cells
cell therapy
cell proliferation
bone mineral density
poor prognosis
bone regeneration
bone marrow
bone loss
human health
skeletal muscle
risk assessment
tissue engineering
mouse model
long non coding rna
binding protein